HBV RNA encapsidation signal epsilon
The HBV RNA encapsidation signal epsilon (HBV_epsilon) is an element essential for HBV virus replication. It is an RNA structure situated near the 5' end of the HBV pregenomic RNA. The structure consists of a lower stem, a bulge region, an upper stem and a tri-loop.The structure was determined and refined through enzymatic probing and NMR spectroscopy. The closure of the tri-loop was not predicted by RNA structure prediction programs but observed in the NMR structure. The regions shown to be critical for encapsidation of the RNA in the viral lifecycle are the bulge, upper stem and tri-loop which interact with the terminal protein domain of the HBV viral polymerase.
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HBV RNA encapsidation signal epsilon
The HBV RNA encapsidation signal epsilon (HBV_epsilon) is an element essential for HBV virus replication. It is an RNA structure situated near the 5' end of the HBV pregenomic RNA. The structure consists of a lower stem, a bulge region, an upper stem and a tri-loop.The structure was determined and refined through enzymatic probing and NMR spectroscopy. The closure of the tri-loop was not predicted by RNA structure prediction programs but observed in the NMR structure. The regions shown to be critical for encapsidation of the RNA in the viral lifecycle are the bulge, upper stem and tri-loop which interact with the terminal protein domain of the HBV viral polymerase.
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The HBV RNA encapsidation sign ...... n of the HBV viral polymerase.
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19,058,606
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HBV
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caption
Predicted secondary structure and sequence conservation of HBV_epsilon
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id
RF01047
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name
HBV RNA encapsidation signal epsilon
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Rfam
RF01047
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RNA type
symbol
HBV_epsilon
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Tax domain
Viruses
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wikiPageUsesTemplate
hypernym
type
comment
The HBV RNA encapsidation sign ...... n of the HBV viral polymerase.
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label
HBV RNA encapsidation signal epsilon
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