Hadacidin
Hadacidin, and hadacidin analogues, have anticancer activity and activity against adenylosuccinate synthetase. Hadacidin is the simplest known naturally occurring hydroxamic acid. The hydroxylamino group is frequently donated by a hydroxylamino acid such as 8-N-hydroxyornithine of the siderochromes. This compound, first isolated and characterized by Kaczka et al. in 1962, seemed well suited for a study of the route of hydroxamic acid biosynthesis. The hydroxamate bond may be considered to be a peptide bond with an oxygen atom on the amide nitrogen, but there is no a priori reason to decide whether the oxygen atom is introduced before or after the formation of the amide bond. In the latter case, formylglycine would be an intermediate in hadacidin biosynthesis. N-Hydroxylation of an amide bo
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Hadacidin
Hadacidin, and hadacidin analogues, have anticancer activity and activity against adenylosuccinate synthetase. Hadacidin is the simplest known naturally occurring hydroxamic acid. The hydroxylamino group is frequently donated by a hydroxylamino acid such as 8-N-hydroxyornithine of the siderochromes. This compound, first isolated and characterized by Kaczka et al. in 1962, seemed well suited for a study of the route of hydroxamic acid biosynthesis. The hydroxamate bond may be considered to be a peptide bond with an oxygen atom on the amide nitrogen, but there is no a priori reason to decide whether the oxygen atom is introduced before or after the formation of the amide bond. In the latter case, formylglycine would be an intermediate in hadacidin biosynthesis. N-Hydroxylation of an amide bo
has abstract
Hadacidin, and hadacidin analo ...... tion to yield the hydroxamate.
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IUPAC name
(N-Hydroxyformamido)acetic acid
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N-Formyl-N-hydroxyglycine
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Wikipage page ID
40,254,200
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Wikipage revision ID
1,026,324,866
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IUPACName
N-Formyl-N-hydroxyglycine
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PIN
acetic acid
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wikiPageUsesTemplate
comment
Hadacidin, and hadacidin analo ...... N-Hydroxylation of an amide bo
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label
Hadacidin
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