The Hampton–Preston House located at 1615 Blanding Street in Columbia, South Carolina, is a historic mansion that was the home of members of the prominent Hampton family. It was listed in the National Register of Historic Places on July 29, 1969. During the latter part of the American Civil War, the house was used as the headquarters of Union Maj. Gen. John A. Logan during the occupation of Columbia. The South Carolina Presbyterian Institute for Young Ladies acquired the mansion in 1890.