Harold E. Wise (1903 – February 27, 1969) was an American football coach. He served as the head football coach at Ohio University in Athens, Ohio from 1947 to 1948, compiling a record of 6–11–1. Wise was a 1928 graduate of Ohio University and was an associate director of the school's alumni board. A native of Wheeling, West Virginia, Wise later worked for Columbia Gas of Ohio. He died on February 27, 1969, at his home in Columbus, Ohio.