Heparin-binding EGF-like growth factor
Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by monocytes and macrophages, due to an affinity for heparin is termed HB-EGF. It has been shown to play a role in wound healing, cardiac hypertrophy, and heart development and function. First identified in the conditioned media of human macrophage-like cells, HB-EGF is an 87-amino acid glycoprotein that displays highly regulated gene expression. Ectodomain shedding results in the soluble mature form of HB-EGF, which influences the mitogenicity and chemotactic factors for smooth muscle cells and fibroblasts. The transme
BAG1DTSFDiphtheriaDiphtheria toxinDtsfE-boxEGF-like domainERBB4Enzyme-linked receptor1,2-dimethoxyethaanErbBHB-EGFHBEGFHBEGF (gene)HEGFLHegflKunitz STI protease inhibitorLeukotriene B4 receptor 2List of human protein-coding genes 2NRD1Proteases in angiogenesisSULF1Tumor microenvironmentZinc finger and BTB domain-containing protein 16
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Heparin-binding EGF-like growth factor
Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by monocytes and macrophages, due to an affinity for heparin is termed HB-EGF. It has been shown to play a role in wound healing, cardiac hypertrophy, and heart development and function. First identified in the conditioned media of human macrophage-like cells, HB-EGF is an 87-amino acid glycoprotein that displays highly regulated gene expression. Ectodomain shedding results in the soluble mature form of HB-EGF, which influences the mitogenicity and chemotactic factors for smooth muscle cells and fibroblasts. The transme
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Heparin-binding EGF-like growt ...... ing cell to cell interactions.
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Heparin-binding EGF-like growt ...... s and fibroblasts. The transme
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Heparin-binding EGF-like growth factor
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