The history of Yarmouth, Maine, is closely tied to its position on the banks of the Royal River and its proximity to Casco Bay, an inlet of the Gulf of Maine, itself a gulf of the Atlantic Ocean. Native Americans originally settled the area, and several wars between them and later European settlers occurred before they were driven from the area for the final time in the mid-18th century. The Maine Historic Preservation Commission has found many of Yarmouth's historic buildings eligible for listing on the National Register of Historic Places, in addition to the twelve that are already included.