Hit to lead
Hit to lead (H2L) also known as lead generation is a stage in early drug discovery where small molecule hits from a high throughput screen (HTS) are evaluated and undergo limited optimization to identify promising lead compounds. These lead compounds undergo more extensive optimization in a subsequent step of drug discovery called lead optimization (LO). The drug discovery process generally follows the following path that includes a hit to lead stage: On average, only one in every 5,000 compounds that enters drug discovery to the stage of preclinical development becomes an approved drug.
BML-190CCR5 receptor antagonistCarpanoneChemMedChemChemical libraryChemogenomicsCompound managementDerek Lowe (chemist)Discovery and development of beta-blockersDrug Discovery Hit to LeadDrug designDrug discoveryDrug discovery hit to leadH2LHigh-content screeningHigh-throughput screeningHigh throughput biologyHit to leadJonathan BaellLead compoundLead optimizationLigand efficiencyLipinski's rule of fiveMDL Information SystemsNatural productRoss D. KingScoring functions for docking
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Hit to lead
Hit to lead (H2L) also known as lead generation is a stage in early drug discovery where small molecule hits from a high throughput screen (HTS) are evaluated and undergo limited optimization to identify promising lead compounds. These lead compounds undergo more extensive optimization in a subsequent step of drug discovery called lead optimization (LO). The drug discovery process generally follows the following path that includes a hit to lead stage: On average, only one in every 5,000 compounds that enters drug discovery to the stage of preclinical development becomes an approved drug.
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Hit to lead (H2L) also known a ...... ment becomes an approved drug.
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Hit to lead (H2L) also known a ...... ment becomes an approved drug.
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Hit to lead
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