Holy Trinity Greek Orthodox Church is a historic Greek Orthodox Church building at 62 Lewis Street in Lowell, Massachusetts. Holy Trinity is one of the many Eastern Orthodox churches in Lowell, along with St. George Antiochian Orthodox Church, Transfiguration of Our Savior Greek Orthodox Church, and St. George Greek Orthodox Church. The church is under the jurisdiction of the Greek Orthodox Archdiocese of America and is locally administered by the Metropolis of Boston. The church is located the Downtown Lowell neighborhood known as The Acre. It was built in 1906 and added to the National Register of Historic Places in 1977. Holy Trinity was the first church built for a Greek Orthodox congregation in the United States. It is known for its golden dome, mosaics, iconography, and rich history.