Interleukin 18
Interleukin-18 (IL18, also known as interferon-gamma inducing factor) is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine. Many cell types, both hematopoietic cells and non-hematopoietic cells, have the potential to produce IL-18. It was first described in 1989 as a factor that induced interferon-γ (IFN-γ) production in mouse spleen cells. Originally, IL-18 production was recognized in Kupffer cells, liver-resident macrophages. However, IL-18 is constitutively expressed in non-hematopoietic cells, such as intestinal epithelial cells, keratinocytes, and endothelial cells. IL-18 can modulate both innate and adaptive immunity and its dysregulation can cause autoimmune or inflammatory diseases.
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AIM2Acute kidney injuryAdaptive NK cellsAdult-onset Still's diseaseAngiogenesis inhibitorBleomycinBone healingCaspase 1Caspase 11Caspase 12Circulating free DNACryopyrin-associated periodic syndromeDapansutrileDepression and immune functionEpigenetics of anxiety and stress–related disordersEpstein–Barr virus-associated lymphoproliferative diseasesFamilial Mediterranean feverGranzyme BHypothermia therapy for neonatal encephalopathyIL-18IL18BPIL18RAPIL18 (gene)IL1AImmunogenic cell deathInflammasomeInflammationInflammatory cytokineInnate lymphoid cellInterbreeding between archaic and modern humansInterleukinInterleukin-18Interleukin-1 familyInterleukin-1 receptor familyInterleukin 33Interleukin 37Interlukin-18List of MeSH codes (D12.644)List of MeSH codes (D12.776)List of MeSH codes (D23)
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Interleukin 18
Interleukin-18 (IL18, also known as interferon-gamma inducing factor) is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine. Many cell types, both hematopoietic cells and non-hematopoietic cells, have the potential to produce IL-18. It was first described in 1989 as a factor that induced interferon-γ (IFN-γ) production in mouse spleen cells. Originally, IL-18 production was recognized in Kupffer cells, liver-resident macrophages. However, IL-18 is constitutively expressed in non-hematopoietic cells, such as intestinal epithelial cells, keratinocytes, and endothelial cells. IL-18 can modulate both innate and adaptive immunity and its dysregulation can cause autoimmune or inflammatory diseases.
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Interleukin-18 (IL18, also kno ...... mune or inflammatory diseases.
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Interleukin-18 (IL18, also kno ...... mune or inflammatory diseases.
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Interleukin 18
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