Interleukin 23
Interleukin-23 is a heterodimeric cytokine composed of an IL12B (IL-12p40) subunit (that is shared with IL12) and the IL23A (IL-23p19) subunit. IL-23 is part of IL-12 family of cytokines. A functional receptor for IL-23 (the IL-23 receptor) has been identified and is composed of IL-12R β1 and IL-23R. Adnectin-2 is binding to IL-23 and compete with IL-23/IL-23R. mRNA of IL-23R is 2,8 kB in length and includes 12 exons. The translated protein contains 629 amino acids, which is a type I penetrating protein includes signal peptide, an N-terminal fibronectin III-like domain and an intracellular part contains 3 potential tyrosine phosphorylation domains. There are 24 variants of splicing of IL-23R in mitogen-activated lymphocytes. IL-23R has some single nucleotide polymorphisms in the domain of
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AlphabodyAnkylosing spondylitisApilimodApremilastBiological therapy for inflammatory bowel diseaseBiopharmaceuticalBrazikumabBriakinumabCARD9Cambridge_Antibody_TechnologyCell-mediated immunityCrisaboroleDisease-modifying antirheumatic drugDopamine receptor D5Giant cell arteritisGuselkumabIL-23IL1RL1Immunomodulatory imide drugInnate lymphoid cellInterleukinInterleukin-12 subunit betaInterleukin-1 familyInterleukin-23Interleukin-23 receptorInterleukin 12 receptor, beta 1 subunitInterleukin 17Interleukin 6K. Christopher GarciaList of therapeutic monoclonal antibodiesMacrophage polarizationManagement of Crohn's diseaseMonoclonal antibody therapyMucosal associated invariant T cellNeuroinflammationOutline of immunologyProstaglandin EP4 receptorPsoriatic arthritisSarcoidosisSergio A. Lira
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Interleukin 23
Interleukin-23 is a heterodimeric cytokine composed of an IL12B (IL-12p40) subunit (that is shared with IL12) and the IL23A (IL-23p19) subunit. IL-23 is part of IL-12 family of cytokines. A functional receptor for IL-23 (the IL-23 receptor) has been identified and is composed of IL-12R β1 and IL-23R. Adnectin-2 is binding to IL-23 and compete with IL-23/IL-23R. mRNA of IL-23R is 2,8 kB in length and includes 12 exons. The translated protein contains 629 amino acids, which is a type I penetrating protein includes signal peptide, an N-terminal fibronectin III-like domain and an intracellular part contains 3 potential tyrosine phosphorylation domains. There are 24 variants of splicing of IL-23R in mitogen-activated lymphocytes. IL-23R has some single nucleotide polymorphisms in the domain of
has abstract
Interleukin-23 is a heterodime ...... lammation and immune function.
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locus supplementary data
OMIM id
PDB ID
RefSeq
Symbol
UniProt
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Wikipage page ID
39,206,341
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1,020,512,415
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AltSymbols
CLMF2, NKSF2, p40
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Arm
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caption
Crystal structure of IL-12B
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EntrezGene
LocusSupplementaryData
OMIM
RefSeq
NM_002187
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NM_016584
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symbol
IL12B
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UniProt
P29460
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wikiPageUsesTemplate
subject
hypernym
comment
Interleukin-23 is a heterodime ...... olymorphisms in the domain of
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label
Interleukin 23
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wasDerivedFrom
isPrimaryTopicOf
name
IL12B
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