JQ1
JQ1 is a thienotriazolodiazepine and a potent inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific protein BRDT in mammals. BET inhibitors structurally similar to JQ1 are being tested in clinical trials for a variety of cancers including NUT midline carcinoma. It was developed by the James Bradner laboratory at Brigham and Women's Hospital and named after chemist Jun Qi. The chemical structure was inspired by patent of similar BET inhibitors by Mitsubishi Tanabe Pharma [WO/2009/084693]. Structurally it is related to benzodiazepines. While widely used in laboratory applications, JQ1 is not itself being used in human clinical trials because it has a short half life.
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JQ1
JQ1 is a thienotriazolodiazepine and a potent inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific protein BRDT in mammals. BET inhibitors structurally similar to JQ1 are being tested in clinical trials for a variety of cancers including NUT midline carcinoma. It was developed by the James Bradner laboratory at Brigham and Women's Hospital and named after chemist Jun Qi. The chemical structure was inspired by patent of similar BET inhibitors by Mitsubishi Tanabe Pharma [WO/2009/084693]. Structurally it is related to benzodiazepines. While widely used in laboratory applications, JQ1 is not itself being used in human clinical trials because it has a short half life.
has abstract
JQ1 is a thienotriazolodiazepi ...... ause it has a short half life.
@en
JQ1 — органическое соединение, ...... ости при попадании в организм.
@ru
JQ1はの一種で、ほ乳類における、、、および精巣特異的タンパ ...... が短かいためヒトの臨床試験においてはJQ1自身は使われない。
@ja
Le « JQ1 », nommé en l’honneur ...... me contraceptif oral masculin.
@fr
CAS number
1268524-70-4
ChEBI
FDA UNII code
1MRH0IMX0W
PubChem
Wikipage page ID
36,949,002
page length (characters) of wiki page
Wikipage revision ID
1,011,993,146
Link from a Wikipage to another Wikipage
CAS number
ChEBI
ChemSpiderID
26,323,622
IUPAC name
-tert-butyl 2-acetate
@en
IUPHAR ligand
PubChem
46,907,787
SMILES
O=COCC
@en
StdInChIKey
DNVXATUJJDPFDM-KRWDZBQOSA-N
@en
wikiPageUsesTemplate
hypernym
comment
JQ1 is a thienotriazolodiazepi ...... ause it has a short half life.
@en
JQ1 — органическое соединение, ...... кции и некоторых форм лейкоза.
@ru
JQ1はの一種で、ほ乳類における、、、および精巣特異的タンパ ...... が短かいためヒトの臨床試験においてはJQ1自身は使われない。
@ja
Le « JQ1 », nommé en l’honneur ...... me contraceptif oral masculin.
@fr
label
JQ1
@en
JQ1
@fr
JQ1
@ja
JQ1
@ru