JTV-519
JTV-519 (K201) is a 1,4-benzothiazepine derivative that interacts with many cellular targets. It has many structural similarities to diltiazem, a Ca2+ channel blocker used for treatment of hypertension, angina pectoris and some types of arrhythmias. JTV-519 acts in the sarcoplasmic reticulum (SR) of cardiac myocytes by binding to and stabilizing the ryanodine receptor (RyR2) in its closed state. It can be used in the treatment of cardiac arrhythmias, heart failure, catecholaminergic polymorphic ventricular tachycardia (CPVT) and store overload-induced Ca2+ release (SOICR). Currently, this drug has only been tested on animals and its side effects are still unknown. As research continues, some studies have also found a dose-dependent response; where there is no improvement seen in failing he
Wikipage redirect
Link from a Wikipage to another Wikipage
primaryTopic
JTV-519
JTV-519 (K201) is a 1,4-benzothiazepine derivative that interacts with many cellular targets. It has many structural similarities to diltiazem, a Ca2+ channel blocker used for treatment of hypertension, angina pectoris and some types of arrhythmias. JTV-519 acts in the sarcoplasmic reticulum (SR) of cardiac myocytes by binding to and stabilizing the ryanodine receptor (RyR2) in its closed state. It can be used in the treatment of cardiac arrhythmias, heart failure, catecholaminergic polymorphic ventricular tachycardia (CPVT) and store overload-induced Ca2+ release (SOICR). Currently, this drug has only been tested on animals and its side effects are still unknown. As research continues, some studies have also found a dose-dependent response; where there is no improvement seen in failing he
has abstract
JTV-519 (K201) is a 1,4-benzot ...... R levels beyond its threshold.
@en
alternative name
K201
@en
IUPAC name
3-(4-Benzyl-1-piperidinyl)-1-( ...... hiazepin-4(5H)-yl)-1-propanone
@en
Wikipage page ID
31,181,238
page length (characters) of wiki page
Wikipage revision ID
979,883,431
Link from a Wikipage to another Wikipage
ImageFile
@en
imagesize
IUPACName
OtherNames
K201
@en
wikiPageUsesTemplate
hypernym
comment
JTV-519 (K201) is a 1,4-benzot ...... improvement seen in failing he
@en
label
JTV-519
@en