Juan Rodríguez Serrano, also known as João Rodrigues Serrão in the Portuguese version, (Fregenal de la Sierra - Cebu, 1521) was a 16th-century Spanish navigator, born in Fregenal de la Sierra, Badajoz, who sailed with Fernão de Magalhães during the first circumnavigation of the world (1519-1521). Serrano was brother or cousin to Francisco Serrão, who was residing in the Spice Islands when the voyage began and whom Magalhaes hoped to meet, but both died almost at the same time in 1521, in the Moluku islands (Ternate) and the Philippines (Mactan Island, Cebu), respectively, before this occurred.