John Thompson Drew (1796 – August 25, 1865) was a mixed blood military and political leader of the Cherokee Nation. Born in 1796, there is little written about his life until he led a company of Cherokee emigrants from Georgia to Indian Territory. The Cherokee Encyclopedia states that he was a participant in the Battle of Claremore Mound in 1818. He is best known for joining the Confederate Army at the outbreak of the American Civil War, when he raised, organized and led the 1st Cherokee Mounted Rifles. He moved his home from the Cherokee Nation to the Chickasaw Nation near the end of the war to escape intra-tribal bloodshed.