Jonathan Knight (September 4, 1789 – August 25, 1864) was an American physician and founding professor of the Yale Medical School. He was a son of Dr. Jonathan Knight, a Surgeon's mate in the Continental Army, and was born in Norwalk, Connecticut. His mother was a daughter of Dr. Asahel Fitch, of Reading, Connecticut. He died in New Haven, aged 75 years, nearly. A funeral discourse by Rev. Dr Bacon, and a commemorativesketch by Prof. F Bacon, M. D., were printed. This article incorporates public domain material from the Yale Obituary Record.