The Killough Massacre is believed to have been both the largest and last Native American attack on white settlers in East Texas. The massacre took place on Friday, October 5, 1838, near Larissa (north of Jacksonville) in the northwestern part of Cherokee County. There were eighteen victims, who included Isaac Killough, Sr., and his extended family (viz. the families of four sons and two daughters). They had immigrated to the Republic of Texas from Talladega County, Alabama, in 1837, settling on December 24 of that year.