Klyuchevsky District (Russian: Ключе́вский райо́н) is an administrative and municipal district (raion), one of the fifty-nine in Altai Krai, Russia. It is located in the west of the krai. The area of the district is 3,043 square kilometers (1,175 sq mi). Its administrative center is the rural locality (a selo) of Klyuchi. As of the 2010 Census, the total population of the district was 18,267, with the population of Klyuchi accounting for 48.7% of that number.