William Lester Self Andrews is an American chemist who makes contributions to the ongoing development of quantum chemistry of metallic complexes. He is the Professor Emeritus of Chemistry at the University of Virginia. He won the Earle K. Plyler Prize for Molecular Spectroscopy in 2010 for "vibrational spectroscopy in cryogenic matrices that combined with quantum calculations, has led to the identification and characterization of many molecules, ions, and complexes across the periodic table".