Levine's sign is a clenched fist held over the chest to describe ischemic chest pain. It is named for Samuel A. Levine (1891–1966), an influential American cardiologist, who first observed that many patients suffering from chest pain made this same sign to describe their symptoms. This clenched fist signal may be seen in patients with acute coronary syndrome (myocardial infarction and angina pectoris).