Lick Branch is a stream in Wayne County in the U.S. state of Missouri. It is a tributary of McKenzie Creek. The stream headwaters arise south of Missouri Route AA at 37°10′42″N 90°43′27″W / 37.17833°N 90.72417°W and the stream flows south to its confluence with McKenzie Creek at 37°08′27″N 90°42′22″W / 37.14083°N 90.70611°W just southwest of the city of Piedmont. Lick Branch was so named on account of a mineral lick near its course.