Lipid-gated ion channels
Lipid-gated ion channels are a class of ion channels whose conductance of ions through the membrane depends directly on lipids. Classically the lipids are membrane resident anionic signaling lipids that bind to the transmembrane domain on the inner leaflet of the plasma membrane with properties of a classic ligand. Other classes of lipid-gated channels include the mechanosensitive ion channels that respond to lipid tension, thickness, and hydrophobic mismatch. A lipid ligand differs from a lipid cofactor in that a ligand derives its function by dissociating from the channel while a cofactor typically derives its function by remaining bound.
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Alcohol_(drug)G protein-coupled inwardly-rectifying potassium channelInward-rectifier potassium channelKCNJ12KCNK2KCNK4Kir2.1Kir6.2KvLQT1KvLQT2Large-conductance mechanosensitive channelLigand (biochemistry)Lipid-gated ion channelMechanosensitive channelsPhosphatidic acidPhosphatidylethanolPhosphatidylglycerolPhospholipase CTransient receptor potential channelTwo-pore-domain potassium channel
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Lipid-gated ion channels
Lipid-gated ion channels are a class of ion channels whose conductance of ions through the membrane depends directly on lipids. Classically the lipids are membrane resident anionic signaling lipids that bind to the transmembrane domain on the inner leaflet of the plasma membrane with properties of a classic ligand. Other classes of lipid-gated channels include the mechanosensitive ion channels that respond to lipid tension, thickness, and hydrophobic mismatch. A lipid ligand differs from a lipid cofactor in that a ligand derives its function by dissociating from the channel while a cofactor typically derives its function by remaining bound.
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Lipid-gated ion channels are a ...... s function by remaining bound.
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992,100,796
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Tetrameric Kir2.2 bound to fo ...... indicate the membrane border.
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name
Lipid-gated ion-channel Kir2.2
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OPM protein
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Kir2.2
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Lipid-gated ion channels are a ...... s function by remaining bound.
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Lipid-gated ion channels
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