There are a number of documented cases of historical figures and distinguished members of society who had kidney stones. This condition is caused by nephrolithiasis, which are more commonly known as kidney stones, or urolithiasis, where the stone forms in the urinary system. These are crystal deposits that can accrete in the urinary system when certain chemical substances become concentrated in the urine. Among the symptoms associated with nephrolithiasis are intense colicky pain, nausea, fever, chills, and the reduction or blockage of urine flow. Historically, the condition of having a kidney or bladder stone was referred to as "the stone" or "the gravel".