Lodge Moor Hospital is a former isolation hospital on Redmires Road in the Lodge Moor area of the City of Sheffield, England. The hospital which opened in 1888 and closed in 1994 initially treated Smallpox but soon broadened its treatment to other infectious diseases and in its latter years expanded to provide more general nursing, notably spinal injuries and chest medicine. At the time of closure, the hospital was operated by the Central Sheffield University Hospitals NHS Trust.