MDia1
mDia1 (also known as Dia1, Drf1 for Diaphanous-related formin-1, Diaph1, KIAA4062, p140mDia, mKIAA4062, or D18Wsu154e) is a member of the protein family called the formins and is a Rho effector. It is the mouse version of the diaphanous homolog 1 of Drosophila. mDia1 localizes to cells' mitotic spindle and midbody, plays a role in stress fiber and filopodia formation, phagocytosis, activation of serum response factor, formation of adherens junctions, and it can act as a transcription factor. mDia1 accelerates actin nucleation and elongation by interacting with barbed ends (fast-growing ends) of actin filaments. The gene encoding mDia1 is located on Chromosome 18 of Mus musculus and named Diap1.
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MDia1
mDia1 (also known as Dia1, Drf1 for Diaphanous-related formin-1, Diaph1, KIAA4062, p140mDia, mKIAA4062, or D18Wsu154e) is a member of the protein family called the formins and is a Rho effector. It is the mouse version of the diaphanous homolog 1 of Drosophila. mDia1 localizes to cells' mitotic spindle and midbody, plays a role in stress fiber and filopodia formation, phagocytosis, activation of serum response factor, formation of adherens junctions, and it can act as a transcription factor. mDia1 accelerates actin nucleation and elongation by interacting with barbed ends (fast-growing ends) of actin filaments. The gene encoding mDia1 is located on Chromosome 18 of Mus musculus and named Diap1.
has abstract
mDia1 (also known as Dia1, Drf ...... has been knocked-out in mice.
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PDB ID
RefSeq
NP_031884.1
UniProt
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Wikipage page ID
27,405,535
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1,023,767,375
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AltSymbols
DRF1
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caption
Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP
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name
Protein diaphanous homolog 1
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RefSeq
NP_031884.1
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symbol
mDia1
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UniProt
o08808
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wikiPageUsesTemplate
hypernym
comment
mDia1 (also known as Dia1, Drf ...... Mus musculus and named Diap1.
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label
MDia1
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wasDerivedFrom
isPrimaryTopicOf
name
Protein diaphanous homolog 1
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