MT-45
MT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opioid activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine). It has been used as a lead compound from which a large family of potent opioid drugs have been developed, including full agonists, partial agonists, and antagonists at the three main opioid receptor subtypes. Fluorinated derivatives of MT-45 such as 2F-MT-45 are significantly more potent as μ-opioid receptor agonists, and one of its main metabolites 1,2-diphenylethylpiperazine also b
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1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazineAD-1211BucinnazineBudipineC24H32N2CM156Controlled Drugs and Substances ActDelucemineDiphenidineDiphenpipenolDrugs controlled by the German BetäubungsmittelgesetzDrugs controlled by the UK Misuse of Drugs ActEphenidineFluorolintaneIC-26LanicemineLefetamineList of Schedule I drugs (US)List of designer drugsList of opioidsMethoxphenidineMetonitazeneNPDPAOpioidRemacemideUWA-001
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MT-45
MT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opioid activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine). It has been used as a lead compound from which a large family of potent opioid drugs have been developed, including full agonists, partial agonists, and antagonists at the three main opioid receptor subtypes. Fluorinated derivatives of MT-45 such as 2F-MT-45 are significantly more potent as μ-opioid receptor agonists, and one of its main metabolites 1,2-diphenylethylpiperazine also b
has abstract
MT-45 (IC-6) is an opioid anal ...... ne also blocks NMDA receptors.
@en
CAS number
52694-52-7 (S) enantiomer
52694-55-0
FDA UNII code
Q2640DPW33
PubChem
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Wikipage page ID
31,291,294
page length (characters) of wiki page
Wikipage revision ID
1,014,174,018
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ATC prefix
None
@en
CAS number
CAS supplemental
ChemSpiderID
IUPAC name
legal DE
Anlage II
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legal UK
Class A
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legal US
Schedule I
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PubChem
routes of administration
SMILES
c3ccccc3CCNCCN1C4CCCCC4
@en
StdInChIKey
IGBRRSIHEGCUEN-UHFFFAOYSA-N
@en
synonyms
MT-45, IC-6
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UNII
Q2640DPW33
@en
Verifiedfields
changed
@en
verifiedrevid
451,607,504
Watchedfields
changed
@en
wikiPageUsesTemplate
hypernym
comment
MT-45 (IC-6) is an opioid anal ...... diphenylethylpiperazine also b
@en
label
MT-45
@en