Main Channel Bridge (Winona) consists of a pair of bridges, the original cantilever bridge, and a concrete box girder bridge completed in 2016, that span the main channel of the Mississippi River in the United States between Winona, Minnesota, and Latsch Island. Another bridge, the North Channel Bridge, connects the island to rural Buffalo County, Wisconsin. The bridge carries Minnesota State Highway 43, which continues as Wisconsin Highway 54 at the Minnesota/Wisconsin state line on the nearby North Channel Bridge; in Winona, it connects to Winona Street.