Manfred (Sicilian: Manfredi di Sicilia; 1232 – 26 February 1266) was the last King of Sicily from the Hohenstaufen dynasty, reigning from 1258 until his death. The natural son of the Holy Roman Emperor Frederick II, Manfred became regent over the kingdom of Sicily on behalf of his nephew Conradin in 1254. As regent he subdued rebellions in the kingdom, until in 1258 he usurped Conradin's rule. After an initial attempt to appease pope Innocent IV he took up the ongoing conflict between the Hohenstaufens and the papacy through combat and political alliances. He defeated the papal army at Foggia on 2 December 1254. Excommunicated by three successive popes, Manfred was the target of a Crusade (1255–66) called first by Pope Alexander IV and then by Urban IV. Nothing came of Alexander's call, bu