Manfredi III Chiaramonte (died November 1391) was a Sicilian nobleman. Of French origins, he was given the County of Modica, then one of the most powerful fiefs in the Kingdom of Sicily, in 1377. He was also made lord of Trapani, Agrigento, Bivona, Licata, Castronovo, Lentini, Palma di Montechiaro and Mussomeli, where he built a castle which still bears his name. Manfredi was governor of Messina and, after having liberated the island of Jerba from Arab pirates, he was made also lord of it. He held court in the Palazzo Chiaramonte of Palermo.