The Manning Manse is a historic house at 56 Chelmsford Road in North Billerica, Massachusetts. Built about 1696, it is one of the oldest surviving buildings in Billerica. It has further associations with local and nationally prominent members of the Manning family, and is a significant early example of historic preservation in the United States. Since the mid-20th century it has typically housed a restaurant, under lease from a family association. It was listed on the National Register of Historic Places in 1982.