Maria Kalapothakes (Greek: Μαρία Καλαποθάκη, Athens 1859-1941) was a Greek physician. She was the first woman physician in modern Greece, prior to Angélique Panayotatou. Maria Kalapothakes was the daughter of the American missionary Martha Hooper Blackler (1830-1871) and the Greek surgeon Michail Kalapothakes (1825-1911). She graduated from a Greek high school and then studied at the Harvard Annex (now Radcliffe College) in the US. She studied at the Medical School of Paris in 1886–1894, and returned to Athens in 1894, were she passed the exams for her medical license of the Medical School at the University of Athens.