Martin Gruebele (born January 10, 1964 in Stuttgart, Germany) is a German-born American physical chemist and biophysicist who is currently James R. Eiszner Professor of Chemistry, Professor of Physics, Professor of Biophysics and Computational Biology at the University of Illinois at Urbana-Champaign where he is the principal investigator of the Gruebele Group. The James R. Eiszner Endowed Chair was previously held by Peter Guy Wolynes.