McDame Creek is a creek located in the Cassiar Land District of British Columbia. The creek flows southeast into Dease River and is south of Good Hope Lake. The creek was discovered in 1874 by a prospector named Harry McDame. McDame Creek was mined for gold in the 19th century. A camp called Centreville contained cabins and stores and served as a trading centre for miners working on McDame Creek in the 19th century. In 1877 a 72 ounce solid gold nugget valued at $1,300 was found in McDame Creek. The solid gold nugget was found by a prospector named Al Freeman, it was the largest found in the province. This nugget was found roughly where 1st N. Fork Creek flows into McDame Creek.