Melanie O'Brian (born 1973 in Toronto, Ontario) is a Canadian curator of contemporary art based in Vancouver, British Columbia. She was Director and Curator of Simon Fraser University Art Galleries, including Audain, Teck, and SFU gallery from 2012-2020. O’Brian was Assistant Curator at the Vancouver Art Gallery (2001-2004). O'Brian has taught at Emily Carr University, Simon Fraser University and the University of British Columbia. O’Brian received her MA in Art History at the University of Chicago, Chicago IL, and her BA in Art History from Reed College, Portland, Oregon.