Mercy Cross High School was a private, Roman Catholic high school in Biloxi, Mississippi, founded in 1981. It was the merger of two other high schools in Biloxi, Sacred Heart High School and Notre Dame High School. Sacred Heart was the all-girls school while Notre Dame was the all-boys school. Mercy Cross was the co-ed merger of the two. The name, Mercy Cross, was derived from the Sisters of Mercy and the Brothers of the Holy Cross, who taught students at schools in the Roman Catholic Diocese of Biloxi for decades. Feeder schools included Nativity of the Blessed Virgin Mary Elementary, Our Lady of Fatima Elementary, Sacred Heart Elementary, and St. Alphonsus Elementary.