Mesela is one of the districts in the Oromia Region of Ethiopia. Part of the West Hararghe Zone, Mesela is bordered on the southwest by the Galetti River which separates it from Chiro, on the northwest by Tulo, and on the east by the East Hararghe Zone. Towns in Mesela include and . Coffee is an important cash crop of this woreda; over 50 square kilometers are planted with this crop. Coffee grown in Mesela is well known for its high quality.