Misty Plowright is one of the first two openly transgender people in the United States to become a candidate representing a major political party for a national office, the other being Misty Snow. She was the first openly transgender candidate to win a major party primary for the Congress. She won the Democratic primary vote in Colorado and went on to challenge Republican Doug Lamborn's five-term Congressional seat representing Colorado's 5th congressional district in the November 8, 2016 United States House of Representatives elections. Lamborn won the election on November 8, 2016.