Monomethyl auristatin E
Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer.
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AGS67EAnaplastic large-cell lymphomaAntibody-drug conjugateBrentuximab vedotinC39H67N5O7Diffuse large B-cell lymphomaDolabella auriculariaEnfortumab vedotinEnteropathy-associated T-cell lymphomaExtranodal NK/T-cell lymphoma, nasal typeGPNMBGlembatumumab vedotinGlobo HIndusatumab vedotinMMAEMarine pharmacognosyMature T-cell lymphomaMonomethyl-auristatin EMonomethyl auristatinMonomethyl auristatin FMonomethylauristatin ENomenclature of monoclonal antibodiesSeagenSponge isolatesVedotin
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Monomethyl auristatin E
Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer.
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Monomethyl auristatin E (MMAE) ...... two as in auristatin E itself.
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مونومثيل أوريستاتين إي (بالإنج ...... ة الملكية فإن اسمه هو فيدوتين.
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alternative name
Monomethylauristatin E
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IUPAC name
(S)-N-((3R,4S,5S)-1-((S)-2-((1 ...... hylamino)butanamido)butanamide
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24,951,332
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972,328,985
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IUPACName
-N--N,3-dimethyl-2-butanamide
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OtherNames
Monomethylauristatin E
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458,641,272
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Monomethyl auristatin E (MMAE) ...... well as other types of cancer.
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مونومثيل أوريستاتين إي (بالإنج ...... ة الملكية فإن اسمه هو فيدوتين.
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label
Monomethyl auristatin E
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مونومثيل أوريستاتين إي
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