Moorook Game Reserve is a protected area in the Australian state of South Australia covering the floodplain on the south side of the River Murray in the localities of Kingston-on-Murray and Moorook immediately south of the section of the Sturt Highway that passes between the towns of Kingston-on-Murray in the west and Cobdogla in the east. It is located about 180 kilometres (110 miles) east north-east of the state capital of Adelaide. In 1980, the game reserve was described as follows: Mostly unmodified, although irrigation drainage and some local effluent seep into one corner of the Reserve.