N-end rule
The N-end rule is a rule that governs the rate of protein degradation through recognition of the N-terminal residue of proteins. The rule states that the N-terminal amino acid of a protein determines its half-life (time after which half of the total amount of a given polypeptide is degraded). The rule applies to both eukaryotic and prokaryotic organisms, but with different strength, rules, and outcome. In eukaryotic cells, these N-terminal residues are recognized and targeted by ubiquitin ligases, mediating ubiquitination thereby marking the protein for degradation. The rule was initially discovered by Alexander Varshavsky and co-workers in 1986. However, only rough estimations of protein half-life can be deduced from this 'rule', as N-terminal amino acid modification can lead to variabili
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N-end rule
The N-end rule is a rule that governs the rate of protein degradation through recognition of the N-terminal residue of proteins. The rule states that the N-terminal amino acid of a protein determines its half-life (time after which half of the total amount of a given polypeptide is degraded). The rule applies to both eukaryotic and prokaryotic organisms, but with different strength, rules, and outcome. In eukaryotic cells, these N-terminal residues are recognized and targeted by ubiquitin ligases, mediating ubiquitination thereby marking the protein for degradation. The rule was initially discovered by Alexander Varshavsky and co-workers in 1986. However, only rough estimations of protein half-life can be deduced from this 'rule', as N-terminal amino acid modification can lead to variabili
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Die N-End Rule beschreibt den ...... ute of Technology beschrieben.
@de
La regola dell'N-terminale è u ...... essere trovati nella sequenza.
@it
N端法則是指蛋白質氨基端上的胺基酸種類,與此蛋白質的存活時間 ...... 苯丙胺酸、天冬胺酸、賴胺酸,約3分鐘
* 精胺酸,約2分鐘
@zh
The N-end rule is a rule that ...... can also be found in sequence.
@en
Zasada końca N – reguła chemic ...... iego pochodzenia, w 1986 roku.
@pl
قاعدة الطرف الأميني أو قاعدة ا ...... ين على سرعة تحلله Proteolyse .
@ar
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Die N-End Rule beschreibt den ...... ute of Technology beschrieben.
@de
La regola dell'N-terminale è u ...... tecnologia del Massachusetts.
@it
N端法則是指蛋白質氨基端上的胺基酸種類,與此蛋白質的存活時間 ...... 苯丙胺酸、天冬胺酸、賴胺酸,約3分鐘
* 精胺酸,約2分鐘
@zh
The N-end rule is a rule that ...... fication can lead to variabili
@en
Zasada końca N – reguła chemic ...... aleźć inne sygnały degradacji.
@pl
قاعدة الطرف الأميني أو قاعدة ا ...... ين على سرعة تحلله Proteolyse .
@ar
label
N-End Rule
@de
N-end rule
@en
N端法則
@zh
Regola dell'N-Terminale
@it
Zasada końca N
@pl
قاعدة الطرف الأميني
@ar