The Nash-Hooper House, also known as the William Hooper House, is a historic house at 118 West Tryon Street in Hillsborough, North Carolina. Built in 1772 by American Revolutionary War general Francis Nash, it was home from 1782-90 to William Hooper, a signer of the United States Declaration of Independence. It is the only known home of Hooper's to survive, and was declared a National Historic Landmark in 1971. It is located in the Hillsborough Historic District; it is a private residence, and is not normally open to the public.