Nebraska Highway 121 is a highway in northeastern Nebraska. It is a discontinuous highway with three segments: * The southern segment begins at Nebraska Highway 32 west of Madison and ends at U.S. Highway 275 north of Battle Creek. * The middle segment begins at Nebraska Highway 13 northwest of Pierce and ends at Nebraska Highway 84 north of Wausa. * The northern segment begins at Nebraska Highway 12 in Crofton and ends at U.S. Highway 81 northeast of Crofton, near the South Dakota border.