Route 380 is a 12-kilometre (7.5 mi) long mostly east–west secondary highway in the northwest portion of New Brunswick, Canada. The route's North-Eastern terminus is north-east of the community of Limestone. The road travels south-east to the community of . The road then takes a sharp turn north to the community of . The road again makes a sharp turn this time towards the south-east passing before entering the community of . The road then switches direction to the south-west again then enters the community of . After this, the road takes its last major directional change south-east passing the community of Anderson Road before ending in .