Nicholas Loftus (1592-1666) was an Irish politician and public official. He was the son of Sir Dudley Loftus and the grandson of Adam Loftus, the Archbishop of Dublin and an influential political figure in Tudor Ireland. His mother Anne Bagenal was from a leading Ulster family headed by Sir Nicholas Bagenal. She later remarried to Lord Sarsfield who became Nicholas' stepfather. In 1623, he married Margaret Chetham, the daughter of Thomas Chetham. After his death in 1666 he was succeeded by his eldest son .