Non-specific effect of vaccines
Non-specific effects of vaccines (also called "heterologous effects" or "off-target effects") are effects which go beyond the specific protective effects against the targeted diseases. Non-specific effects can be strongly beneficial by increasing protection against non-targeted infections. This has been shown with two live attenuated vaccines, BCG vaccine and measles vaccine, through multiple randomized controlled trials. Theoretically, non-specific effects of vaccines may be detrimental, increasing overall mortality despite providing protection against the target diseases. Although observational studies suggest that diphtheria-tetanus-pertussis vaccine (DTP) may be detrimental, these studies are at high risk of bias and have failed to replicate when conducted by independent groups.
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Attenuated vaccineBCG vaccineHeterologous effectsMeasles vaccineNon-specific effectNon-specific effect of vaccineNon-specific effects of vaccinesNon-targeted effect of vaccinesNon-targeted effects of vaccinesNon specific effect of vaccineNon specific effect of vaccinesNon specific effects of vaccinesOff-target effectOff-target effectsPeter AabyVaccineWillardiine
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Non-specific effect of vaccines
Non-specific effects of vaccines (also called "heterologous effects" or "off-target effects") are effects which go beyond the specific protective effects against the targeted diseases. Non-specific effects can be strongly beneficial by increasing protection against non-targeted infections. This has been shown with two live attenuated vaccines, BCG vaccine and measles vaccine, through multiple randomized controlled trials. Theoretically, non-specific effects of vaccines may be detrimental, increasing overall mortality despite providing protection against the target diseases. Although observational studies suggest that diphtheria-tetanus-pertussis vaccine (DTP) may be detrimental, these studies are at high risk of bias and have failed to replicate when conducted by independent groups.
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Non-specific effects of vaccin ...... tion in immunization programs.
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Non-specific effects of vaccin ...... nducted by independent groups.
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Non-specific effect of vaccines
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