North Carolina Highway 345 (NC 345) is a primary state highway in the U.S. state of North Carolina connecting Wanchese and Manteo on Roanoke Island. The highway begins at The Lane and Thicket Lump Drive south of the town marina. Following Mill Landing Road through Wanchese, the road eventually becomes the western boundary for the Roanoke Island Marshes Dedicated Nature Preserve, before reaching its northern terminus at US 64.