Oclacitinib
Oclacitinib (brand name Apoquel) is a veterinary medication used in the control of atopic dermatitis and pruritus from allergic dermatitis in dogs at least 12 months of age. Chemically, it is a synthetic cyclohexylamino pyrrolopyrimidine janus kinase inhibitor that is relatively selective for JAK1. It inhibits signal transduction when the JAK is activated and thus helps downregulate expression of inflammatory cytokines. While oclacitinib is effective, its long-term safety is currently unknown. Oclacitinib was approved by the FDA in 2013.
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Oclacitinib
Oclacitinib (brand name Apoquel) is a veterinary medication used in the control of atopic dermatitis and pruritus from allergic dermatitis in dogs at least 12 months of age. Chemically, it is a synthetic cyclohexylamino pyrrolopyrimidine janus kinase inhibitor that is relatively selective for JAK1. It inhibits signal transduction when the JAK is activated and thus helps downregulate expression of inflammatory cytokines. While oclacitinib is effective, its long-term safety is currently unknown. Oclacitinib was approved by the FDA in 2013.
has abstract
Oclacitinib (brand name Apoque ...... s approved by the FDA in 2013.
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alternative name
Apoquel
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Bioavailability
CAS number
1208319-26-9
ChEMBL
FDA UNII code
99GS5XTB51
KEGG
PubChem
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Wikipage page ID
53,282,326
page length (characters) of wiki page
Wikipage revision ID
1,015,020,444
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ATC prefix
D11
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ATC suffix
AH90
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ATCvet
yes
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bioavailability
CAS number
ChEMBL
ChemSpiderID
28,528,036
elimination half-life
excretion
Mostly liver
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image
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IUPAC name
N-Methyl{trans-4-[methylamino]cyclohexyl}methanesulfonamide
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KEGG
D10141
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legal status
Rx-only
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metabolism
protein bound
PubChem
44,631,938
routes of administration
By mouth
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SMILES
CNSC[C@@H]1CC[C@H]Nc2[nH]cnc3nccc23
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StdInChIKey
HJWLJNBZVZDLAQ-HAQNSBGRSA-N
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synonyms
PF-03394197
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tradename
Apoquel
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wikiPageUsesTemplate
comment
Oclacitinib (brand name Apoque ...... s approved by the FDA in 2013.
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label
Oclacitinib
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