State Route 291 (SR 291) is a 4.14-mile-long (6.66 km) north–south state highway in the northeastern quadrant of the U.S. state of Ohio. The southern terminus of the highway is at a T-intersection with Fowles Road in Middleburg Heights, nearly 0.50 miles (0.80 km) west of where Fowles Road meets U.S. Route 42. Its northern terminus is at a signalized T-intersection with SR 17 on the border between Brook Park and Cleveland, immediately west of where SR 17 passes underneath Interstate 71 south of Interstate 480.