Olga Simzis (1887, Odessa, Russian Empire – ?) was an operatic soprano who was active in the United States, Italy and Latin America from 1906 to 1941. She created the role of Ermyntrude in Pietro Mascagni's opera Isabeau in its world premiere conducted by the composer at the Teatro Coliseo in Buenos Aires in 1911. She also sang the role of Gilda in some scenes of one of the first complete recordings of Giuseppe Verdi's Rigoletto (made in 1916–1917 by La voce del padrone with the company of La Scala under the direction of Carlo Sabajno), where she substituted the first-cast soprano Ayres Borghi-Zerni.