Oxyanion hole
An oxyanion hole is a pocket in the active site of an enzyme that stabilizes transition state negative charge on a deprotonated oxygen or alkoxide. The pocket typically consists of backbone amides or positively charged residues. Stabilising the transition state lowers the activation energy necessary for the reaction, and so promotes catalysis. For example, proteases such as chymotrypsin contain an oxyanion hole to stabilise the tetrahedral intermediate anion formed during proteolysis and protects substrate's negatively charged oxygen from water molecules. Additionally, it may allow for insertion or positioning of a substrate, which would suffer from steric hindrance if it could not occupy the hole (such as BPG in hemoglobin). Enzymes that catalyse multi-step reactions can have multiple oxy
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(S)-hydroxynitrile lyase2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseBiosynthesis of doxorubicinCatalytic triadDD-transpeptidaseEnoyl CoA isomeraseEnzymeEnzyme catalysisHydrogen-bond catalysisJuliá–Colonna epoxidationLipoprotein lipaseLow-barrier hydrogen bondMyristoylationOxanion holePhotoactive yellow proteinPlatensimycinPropionyl-CoA carboxylaseSedolisinSteroid Delta-isomeraseTrypsinogenΒ-lactam antibiotic
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Oxyanion hole
An oxyanion hole is a pocket in the active site of an enzyme that stabilizes transition state negative charge on a deprotonated oxygen or alkoxide. The pocket typically consists of backbone amides or positively charged residues. Stabilising the transition state lowers the activation energy necessary for the reaction, and so promotes catalysis. For example, proteases such as chymotrypsin contain an oxyanion hole to stabilise the tetrahedral intermediate anion formed during proteolysis and protects substrate's negatively charged oxygen from water molecules. Additionally, it may allow for insertion or positioning of a substrate, which would suffer from steric hindrance if it could not occupy the hole (such as BPG in hemoglobin). Enzymes that catalyse multi-step reactions can have multiple oxy
has abstract
An oxyanion hole is a pocket i ...... sition states in the reaction.
@en
Das Oxyanion-Loch ist eine For ...... Proteinligation zu verwenden.
@de
Het oxyanion-gat (Engels: oxya ...... osfoglyceraat in hemoglobine).
@nl
Un agujero de oxianión es un b ...... ansición durante la reacción.
@es
Un trou oxyanion est une cavit ...... oglycérate dans l'hémoglobine.
@fr
负氧离子洞(英語:oxyanion hole)能够稳定去质子 ...... 步反应的酶可以具有多个负氧离子洞,其稳定反应中的不同过渡态。
@zh
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An oxyanion hole is a pocket i ...... eactions can have multiple oxy
@en
Das Oxyanion-Loch ist eine For ...... senergie der Reaktion gesenkt.
@de
Het oxyanion-gat (Engels: oxya ...... inozuurresidu's, zoals lysine.
@nl
Un agujero de oxianión es un b ...... strato, que de otro modo sufri
@es
Un trou oxyanion est une cavit ...... n au substrat de deux façons :
@fr
负氧离子洞(英語:oxyanion hole)能够稳定去质子 ...... 步反应的酶可以具有多个负氧离子洞,其稳定反应中的不同过渡态。
@zh
label
Agujero de oxianión
@es
Oxyanion hole
@en
Oxyanion-Loch
@de
Oxyanion-gat
@nl
Trou oxyanion
@fr
负氧离子洞
@zh
산소 음이온 구멍
@ko