P53 upregulated modulator of apoptosis
The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. In humans, the Bcl-2-binding component 3 protein is encoded by the BBC3 gene. The expression of PUMA is regulated by the tumor suppressor p53. PUMA is involved in p53-dependent and -independent apoptosis induced by a variety of signals, and is regulated by transcription factors, not by post-translational modifications. After activation, PUMA interacts with antiapoptotic Bcl-2 family members, thus freeing Bax and/or Bak which are then able to signal apoptosis to the mitochondria. Following mitochondrial dysfunction, the caspase cascade is activated ultimately leading to cell death.
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ATG7Anticancer geneBBC3 (disambiguation)BBC3 (gene)BH3 interacting-domain death agonistBcl-21,2-dimethoxyethaanCell cycleExtranodal NK/T-cell lymphoma, nasal typeFOXO3HSPA8Karen VousdenList of human protein-coding genes 1MonocrotophosOmigapilPhorbol-12-myristate-13-acetate-induced protein 1Programmed cell deathPuma
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P53 upregulated modulator of apoptosis
The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. In humans, the Bcl-2-binding component 3 protein is encoded by the BBC3 gene. The expression of PUMA is regulated by the tumor suppressor p53. PUMA is involved in p53-dependent and -independent apoptosis induced by a variety of signals, and is regulated by transcription factors, not by post-translational modifications. After activation, PUMA interacts with antiapoptotic Bcl-2 family members, thus freeing Bax and/or Bak which are then able to signal apoptosis to the mitochondria. Following mitochondrial dysfunction, the caspase cascade is activated ultimately leading to cell death.
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The p53 upregulated modulator ...... imately leading to cell death.
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994,051,600
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April 2017
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The p53 upregulated modulator ...... imately leading to cell death.
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P53 upregulated modulator of apoptosis
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